1-Naphthaleneacetonitrile → 1-Naphthylmalononitrile

HRID 1594994

반응식

HRID 1594994 반응식
[C:1]1([CH2:11][C:12]#[N:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.ClC1C=CC=CC=1CS[C:19]#[N:20].C([N-]C(C)C)(C)C.[Li+].[OH-].[Na+]>C1C=CC=CC=1>[C:1]1([CH:11]([C:19]#[N:20])[C:12]#[N:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 4

HCID 85961-NaphthaleneacetonitrileHCID 14798Sodium HydroxideHCID 2867232-Chlorobenzyl ThiocyanateHCID 2724682Lithium diisopropylamide

생성물 1

HCID 109103631-Naphthylmalononitrile

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

With stirring and cooling, 0.3 mol of 1-naphthylaceto-nitrile and then, dropwise, 0.6 mol of 2-chlorobenzyl thiocyanate are added to a solution of 0.65 mol of lithium diisopropylamide in benzene. After one hour, the reaction mixture is introduced into 1 l of 0.3 molar NaOH, and the mixture is allowed to stand for a while and then the two phases which are formed are separated. The aqueous solution is neutralized by adding hydrochloric acid and allowed to stand overnight. The precipitated product is filtered off with suction, dried and purified by recrystallization from ethanol.

후처리

  1. temperaturecooling
  2. customthe two phases which are formed
  3. customare separated
  4. additionby adding hydrochloric acid
  5. waitto stand overnight
  6. filtrationThe precipitated product is filtered off with suction
  7. customdried
  8. custompurified by recrystallization from ethanol

출처 및 근거

ORD 기록
ord-2077ac4c27f64b2e8445d3db60f6cb2d
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06284889B1

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