Benzylamine → HCID 21704006, 화합물

HRID 1595318노트

반응식

HRID 1595318 반응식
[CH:1]1([C:7](=O)[C:8](=[N:16]O)[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1C=CC=CC=1>[CH:1]1([C:7]2[NH:26][C:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][C:8]=2[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 178451306HCID 178451306, 화합물

생성물 1

HCID 21704006HCID 21704006, 화합물수율 27.1%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

tert-Butyl 3-cyclohexyl-2-hydroxyimino-3-oxopropionate (2.6 g) and benzylamine (2.1 g) were dissolved in benzene (50 ml), and the mixture was refluxed under heating for 16 hr. The solvent was concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (chloroform:ethyl acetate=8:1) to give tert-butyl 5-cyclohexyl-2-phenylimidazole-4-carboxylate (0.90 g), melting point 222-223° C.

후처리

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 16 hr
  3. concentrationThe solvent was concentrated under reduced pressure
  4. customThe obtained residue was purified by silica gel chromatography (chloroform:ethyl acetate=8:1)

출처 및 근거

ORD 기록
ord-2d2ec05359ab417f9b6a7f3bc42bc553
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288061B1

반응 노트

불러오는 중…