[4-(Morpholin-4-ylmethyl)phenyl]methanamine → Ethyl 5-(4-chlorophenyl)-2-[4-(morpholinomethyl)phenyl]imidazole-4-carboxylate

HRID 1595376

반응식

HRID 1595376 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH2:14][NH2:15])=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23](=O)[C:24](=[N:30]O)[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:19][CH:18]=1>N1C=CC=CC=1>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[NH:15][C:14]([C:11]3[CH:10]=[CH:9][C:8]([CH2:7][N:4]4[CH2:3][CH2:2][O:1][CH2:6][CH2:5]4)=[CH:13][CH:12]=3)=[N:30][C:24]=2[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 2795501[4-(Morpholin-4-ylmethyl)phenyl]methanamineHCID 178472894HCID 178472894, 화합물

생성물 1

HCID 178470186Ethyl 5-(4-chlorophenyl)-2-[4-(morpholinomethyl)phenyl]imidazole-4-carboxylate수율 61.5%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

4-(Morpholinomethyl)phenylmethylamine (8 g) and ethyl 3-(4-chlorophenyl) -2-hydroxyimino-3-oxopropionate (8.26 g) were dissolved in pyridine (120 ml) and the mixture was refluxed under heating for 12 hr. The solvent was evaporated under reduced pressure and the obtained residue was subjected to silica gel column chromatography to give the objective ethyl 5-(4-chlorophenyl)-2-[4-(morpholinomethyl)phenyl]imidazole-4-carboxylate (8.46 g), melting point 183-185° C.

후처리

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 12 hr
  3. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-d44807d35368431c8724c55ddde81c27
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288061B1

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