Dimethylamine, hydrochloride → N-(4-dimethylaminomethylphenylmethyl)acetamide

HRID 1595377노트

반응식

HRID 1595377 반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1.Cl.[CH3:15][NH:16][CH3:17].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:15][N:16]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1)[CH3:17]

참가 물질

5

반응물 3

HCID 10473Dimethylamine, hydrochlorideHCID 11430Potassium CarbonateHCID 15550682223512-41-2

생성물 1

HCID 21703715N-(4-dimethylaminomethylphenylmethyl)acetamide수율 136.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

N-(4-Chloromethylphenylmethyl)acetamide (20.0 g) and dimethylamine hydrochloride (9.1 g) were dissolved in acetonitrile (190 ml), and potassium carbonate (28 g) was added. The mixture was refluxed under heating overnight. An insoluble solid was filtered off and the solvent was evaporated to give the objective N-(4-dimethylaminomethylphenylmethyl)acetamide (28.4 g) as an oil.

후처리

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating overnight
  3. filtrationAn insoluble solid was filtered off
  4. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-003b84edd6804181a283ab5e3d577154
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288061B1

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