Diethyl Ether → Benzeneethanol, 4-(acetyloxy)-

HRID 1595511

반응식

HRID 1595511 반응식
[OH-].[K+].[OH:3][C:4]1[CH:12]=[CH:11][C:7]([CH2:8][CH2:9][OH:10])=[CH:6][CH:5]=1.[C:13](OC(=O)C)(=[O:15])[CH3:14].C(OCC)C>O.O1CCCC1>[CH3:14][C:13]([O:3][C:4]1[CH:12]=[CH:11][C:7]([CH2:8][CH2:9][OH:10])=[CH:6][CH:5]=1)=[O:15]

참가 물질

7

반응물 4

HCID 3283Diethyl EtherHCID 7918Acetic AnhydrideHCID 10393TyrosolHCID 14797Potassium Hydroxide

생성물 1

HCID 586676Benzeneethanol, 4-(acetyloxy)-수율 67%

시약·촉매·용매 2

HCID 962Water용매2회HCID 8028Tetrahydrofuran용매

실험 절차

5.6 g (0.1 mole) potassium hydroxide in 10 ml water was added to a cooled solution of 13.8 g (0.1 mole) p-hydroxyphenethyl alcohol in 50 ml tetrahydrofuran. 10.2 g (0.1 mole) acetic anhydride was slowly added under stirring. After 2 hours diethyl ether and water were added. The phases were separated and the organic phase was dried, filtered and evaporated in vacuo. The product contained 15% starting material and was therefore redissolved in diethyl ether and washed twice with dilute sodium carbonate. Drying, filtration and evaporation of solvents in vacuo gave 12 g (yield 67%) of 2-(4-methylcarbonyloxyphenyl)-1-ethanol which was used without further purification.

후처리

  1. customThe phases were separated
  2. customthe organic phase was dried
  3. filtrationfiltered
  4. customevaporated in vacuo
  5. dissolutionwas therefore redissolved in diethyl ether
  6. washwashed twice with dilute sodium carbonate
  7. customDrying
  8. filtrationfiltration and evaporation of solvents in vacuo

출처 및 근거

ORD 기록
ord-ecd20afd2ef34717a3827cdc48a36da5
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288096B1

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