Hydrochloric Acid → 4-[3-(3,7-Diazabicyclo[3.3.1]non-3-yl)-2-hydroxypropoxy]benzonitrile

HRID 1596433노트

반응식

HRID 1596433 반응식
Cl.[C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH:10]([OH:28])[CH2:11][N:12]2[CH2:19][CH:18]3[CH2:20][CH:14]([CH2:15][N:16](C(OC(C)(C)C)=O)[CH2:17]3)[CH2:13]2)=[CH:6][CH:5]=1)#[N:3]>CCOC(C)=O>[CH:14]12[CH2:20][CH:18]([CH2:17][NH:16][CH2:15]1)[CH2:19][N:12]([CH2:11][CH:10]([OH:28])[CH2:9][O:8][C:7]1[CH:6]=[CH:5][C:4]([C:2]#[N:3])=[CH:30][CH:29]=1)[CH2:13]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 53796099HCID 53796099, 화합물

생성물 1

HCID 217019464-[3-(3,7-Diazabicyclo[3.3.1]non-3-yl)-2-hydroxypropoxy]benzonitrile수율 90%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

HCl-saturated EtOAc (600 mL) was added to a solution of tert-butyl 7-[3-(4-cyanophenoxy)-2-hydroxypropyl]-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (62 g; see Example 2 below) in EtOAc (600 mL) and the mixture was stirred at rt. for 4 h. The solvent was removed under reduced pressure, the residue was dissolved in MeCN (1.3 L) and K2CO3 (100 g) was added. The suspension was stirred for 12 h and filtered. Concentration of the filtrate gave the title compound in a 90% yield.

후처리

  1. customThe solvent was removed under reduced pressure
  2. dissolutionthe residue was dissolved in MeCN (1.3 L)
  3. additionK2CO3 (100 g) was added
  4. stirringThe suspension was stirred for 12 h
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-5c92d3e1de204a6e9ae1a14d8cc0f618
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06291475B1

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