Sodium Cyanide → 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile

HRID 1597264

반응식

HRID 1597264 반응식
Cl.[NH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH2:8]([N:15]1[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[C-:22]#[N:23].[Na+]>CO.O>[CH2:8]([N:15]1[CH2:20][CH2:19][C:18]([C:22]#[N:23])([N:2]2[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]2)[CH2:17][CH2:16]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

6

반응물 3

HCID 8929Sodium CyanideHCID 192201-Benzyl-4-piperidoneHCID 2723721Piperidine, hydrochloride (1:1)

생성물 1

HCID 27334341'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile수율 95.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

12.16 g of piperidine hydrochloride and 18.9 g of 1-benzylpiperid-4-one are dissolved in 50 ml of an MeOH/H20 mixture (50/50; v/v). 5.3 g of NaCN dissolved in 20 ml of water are added dropwise. After stirring for 48 hours, the precipitate formed is filtered, rinsed with water and dried to give 27 g of the expected product.

후처리

  1. additionare added dropwise
  2. customthe precipitate formed
  3. filtrationis filtered
  4. washrinsed with water
  5. customdried

출처 및 근거

ORD 기록
ord-c96c12078ae548d29d26a151cbb5c173
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06294537B1

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