4-Methylindoline → 6,7-Dimethoxy-4-(4-methyl-2,3-dihydro-indol-1-yl)-quinazoline

HRID 1597929

반응식

HRID 1597929 반응식
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][NH:6]2.Cl[C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1>CC(O)C>[CH3:23][O:22][C:19]1[CH:20]=[C:21]2[C:16](=[CH:17][C:18]=1[O:24][CH3:25])[N:15]=[CH:14][N:13]=[C:12]2[N:6]1[C:7]2[C:3](=[C:2]([CH3:1])[CH:10]=[CH:9][CH:8]=2)[CH2:4][CH2:5]1

참가 물질

4

반응물 2

HCID 5837034-MethylindolineHCID 27693644-Chloro-6,7-dimethoxyquinazoline

생성물 1

HCID 189327996,7-Dimethoxy-4-(4-methyl-2,3-dihydro-indol-1-yl)-quinazoline수율 94%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 94% yield from 4-methyl-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 174°-175° C.; LC-MS: 322 (MH+); anal. RP18-HPLC RT: 4.85 min.).

출처 및 근거

ORD 기록
ord-2f60dc0806f4460ab0297b10e7ff175f
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05736534

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