Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylindoline → 6,7-Dimethoxy-4-(4-methyl-2,3-dihydro-indol-1-yl)-quinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylindoline | HCID 583703 | — |
| 반응물 | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 6,7-Dimethoxy-4-(4-methyl-2,3-dihydro-indol-1-yl)-quinazoline | HCID 18932799 | 94% |
반응 단계
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 94% yield from 4-methyl-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 174°-175° C.; LC-MS: 322 (MH+); anal. RP18-HPLC RT: 4.85 min.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05736534 |
| 출처 데이터셋 | uspto-grants-1998_04 |
| ORD ID | ord-2f60dc0806f4460ab0297b10e7ff175f |
| 출처 메모 | uspto-grants-1998_04 |