Hydrochloric Acid → HCID 18932808, 화합물

HRID 1597934노트

반응식

HRID 1597934 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][NH:9]2)=[CH:5][CH:4]=1.[Cl:12][C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][N:14]=1.Cl>CC(O)C>[ClH:12].[CH3:24][O:23][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][C:19]=1[O:25][CH3:26])[N:16]=[CH:15][N:14]=[C:13]2[N:9]1[C:10]2[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:11]=2)[CH2:7][CH2:8]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 64275496-methoxy-2,3-dihydro-1H-indole

생성물 1

HCID 18932808HCID 18932808, 화합물수율 91%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 91% yield from 6-methoxy-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. The HCl salt was generated from the purified free base according to a procedure analogous to that given in Example 2. (M.P. 246°-247° C.(dec); LC-MS: 338 (MH+); anal. RP18-HPLC RT: 4.27 min.).

출처 및 근거

ORD 기록
ord-5ad33702340c440982775d51416b5dc6
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05736534

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