2-Amino-1-phenylpropan-1-ol hydrochloride → (1S,2R)-(+)-Norephedrine

HRID 1598295

반응식

HRID 1598295 반응식
[CH3:1][CH:2]([NH2:11])[CH:3]([OH:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.Cl.[OH-].[Na+]>O>[CH3:1][CH:2]([NH2:11])[CH:3]([OH:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 90652-Amino-1-phenylpropan-1-ol hydrochlorideHCID 14798Sodium Hydroxide

생성물 1

HCID 4786(1S,2R)-(+)-Norephedrine

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

Phenylpropanolamine hydrochloride was dissolved in the water and to this solution there was added, rapidly with stirring, 20 gm of sodium hydroxide dissolved in 100 ml of water. The mixture was allowed to stand at 10° C. overnight. Crystals of the free base were filtered, washed with water and dried in vacuum over calcium chloride. This process yielded 59 gm of free base phenylpropanolamine.

후처리

  1. additionwas added
  2. filtrationCrystals of the free base were filtered
  3. washwashed with water
  4. dry with materialdried in vacuum over calcium chloride

출처 및 근거

ORD 기록
ord-8f8fd49571a64745887468f718f48809
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05736573

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