Methylhydrazine → HCID 178481741, 화합물

HRID 1598510노트

반응식

HRID 1598510 반응식
[CH3:1][NH:2][NH2:3].[Cl:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([Cl:15])[C:6]=1[C:16](=O)[CH2:17][C:18]([O:20]CC)=O>C(O)C>[Cl:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([Cl:15])[C:6]=1[C:16]1[CH:17]=[C:18]([OH:20])[N:2]([CH3:1])[N:3]=1

참가 물질

4

반응물 2

HCID 6061MethylhydrazineHCID 18929426Ethyl 3-(2,6-dichloro-4-trifluoromethylphenyl)-3-oxopropionate

생성물 1

HCID 178481741HCID 178481741, 화합물수율 49.4%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of 1.0 g of methylhydrazine in 15 ml of ethanol was added dropwise to 6.0 g of ethyl 3-(2,6-dichloro-4-trifluoromethylphenyl)-3-oxopropionate (5) in 50 ml of ethanol at room temperature, and the mixture was thereafter stirred at room temperature for 1 hour and further refluxed overnight. The reaction mixture was concentrated under reduced pressure to obtain a residue, which was washed with hexane to give 2.8 g of the desired compound in the form of white crystals (crude yield 50.0%).

후처리

  1. temperaturefurther refluxed overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customto obtain a residue, which
  4. washwas washed with hexane

출처 및 근거

ORD 기록
ord-cf85e18857ea44df8b141bc734135e0f
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05739083

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