1,1'-Carbonyldiimidazole → (3aRS,4RS,6SR,7aSR)-6-hydroxymethyl-4-(2-fluorophenyl)-2-(benzyloxyphenylacetyl)perhydroisoindol-4-ol

반응식

[C:1]([N:8]1[CH:12]=[CH:11]N=[CH:9]1)(N1C=CN=C1)=[O:2].[CH2:13]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27]C(O)=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.Cl.[OH:32][CH2:33][CH:34]1[CH2:42][CH:41]2C(CNC2)[C:36]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=2[F:50])([OH:43])[CH2:35]1.C(N(C(C)C)CC)(C)C>ClCCl>[OH:32][CH2:33][CH:34]1[CH2:42][CH:41]2[CH:11]([CH2:12][N:8]([C:1](=[O:2])[CH:21]([O:20][CH2:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:27]=3)[CH2:9]2)[C:36]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=2[F:50])([OH:43])[CH2:35]1