Isopropanol → 6-Isopropoxy-2-methylamino-3-nitropyridine
반응식
Cl[C:2]1[N:7]=[C:6]([NH:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][CH:3]=1.[H-].[Na+].[CH:15]([OH:18])([CH3:17])[CH3:16]>CN(C)C=O>[CH:15]([O:18][C:2]1[N:7]=[C:6]([NH:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][CH:3]=1)([CH3:17])[CH3:16]참가 물질
5
실험 절차
A procedure similar to that described in Preparation 88 was repeated, except that 6.00 g of 6-chloro-2-methylamino-3-nitropyridine (prepared as described in Preparation 66), 1.54 9 of sodium hydride (as a 55% by weight dispersion in mineral oil), 2.7 ml of isopropanol and 150 ml of dimethylformamide were used. After working up the product as described in preparation 88, the resulting crude product was crystallized by trituration with isopropanol, to give 6.10 g of the title compound, melting at 75°-76° C.
후처리
- customA procedure similar to that described in Preparation 88
- customas described in preparation 88
- customthe resulting crude product was crystallized by trituration with isopropanol
출처 및 근거
- ORD 기록
- ord-8e958eda339a4c15926fad6fabdac83d
- 출처 데이터셋
- uspto-grants-1998_04
- 특허 번호
- US05739345
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