Hydrochloric Acid → 1-methyl-4-oxo-7-(trifluoromethyl)-5H-imidazo[1,2-a]quinoxaline-2-carboxylic acid

HRID 1599409노트

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HRID 1599409 반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[N:9]2[C:23]=1[CH3:24])=[O:5])C.O.Cl>[OH-].[K+]>[C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:20])([F:21])[F:22])[CH:14]=3)[N:9]2[C:23]=1[CH3:24])([OH:5])=[O:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 15224969HCID 15224969, 화합물

생성물 1

HCID 98397041-methyl-4-oxo-7-(trifluoromethyl)-5H-imidazo[1,2-a]quinoxaline-2-carboxylic acid수율 74.6%

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

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온도
80 °C

실험 절차

A suspension of 2-ethoxycarbonyl-1-methyl-7-trifluoromethylimidazo [1,2-a]quinoxalin-4(5H)-one (960 mg, 2.8 mmol) in 2M potassium hydroxide (30 ml) was stirred at 80° C. for 4 h. The reaction mixture was added water (25 ml) and pH adjusted to pH 7 with 1N hydrochloride acid. The precipitate was filtered off and washed with water. Recrystallization from glacial acetic acid afforded 650 mg (74%) of the title compound as the acetate. M.p. >250° C.

후처리

  1. filtrationThe precipitate was filtered off
  2. washwashed with water
  3. customRecrystallization from glacial acetic acid

출처 및 근거

ORD 기록
ord-86f97a0cfbce484890ff5851edebd6f3
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05741785

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