Hydrochloric Acid → Methyl 4-[2-(imidazol-2-yl)ethyl]benzoate hydrochloride

HRID 1599936노트

반응식

HRID 1599936 반응식
[C:1]([CH2:3][CH2:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)#[N:2].CO.[ClH:17].CO[CH:20](OC)[CH2:21][NH2:22]>CCOCC>[ClH:17].[NH:2]1[CH:20]=[CH:21][N:22]=[C:1]1[CH2:3][CH2:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 89728Aminoacetaldehyde dimethyl acetalHCID 13308299Methyl 4-(2-cyanoethyl)benzoate

생성물 1

HCID 18928585Methyl 4-[2-(imidazol-2-yl)ethyl]benzoate hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Nitrile 23-3 (400 mg, 2.11 mmol) was dissolved in 10 mL Et2O at 0° MeOH (289 μL, 4.2 mmol) was added, the mixture was saturated with anhydrous HCl. Once the white ppt. formed, the solvent was evaporated and replaced with MeOH (5 mL), cooled to 0°, and aminoacetaldehyde dimethylacetal (250 μL, 2.3 mmol) was added. The reaction was heated to reflux for 3 days then concentrated, diluted in 10 mL 6 N HCl and concentrated again providing 23-4 as a solid.

후처리

  1. additionwas added
  2. customformed
  3. customthe solvent was evaporated
  4. temperaturecooled to 0°
  5. temperatureThe reaction was heated
  6. temperatureto reflux for 3 days
  7. concentrationthen concentrated
  8. additiondiluted in 10 mL 6 N HCl
  9. concentrationconcentrated again

출처 및 근거

ORD 기록
ord-4c13116610bc489a8df6eaf77cee80ba
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05741796

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