N-bromobutanimide → HCID 22625625, 화합물

HRID 1600554노트

반응식

HRID 1600554 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]2[N:15]([CH:16]=1)[CH2:14][CH2:13][S:12]2.[Br:17]N1C(=O)CCC1=O>CN(C)C=O.O>[Br:17][C:16]1[N:15]2[C:11]([S:12][CH2:13][CH2:14]2)=[N:10][C:9]=1[C:3]1[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=1[Cl:1]

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 141451006-(2,4-Dichlorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole

생성물 1

HCID 22625625HCID 22625625, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

The 6-(2,4-dichlorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole (0.6 g) prepared above and N-bromosuccinimide (0.45 g) were dissolved in dimethylformamide (5 ml). The mixture was heated to reflux and stirred for 18 h at room temperature. The mixture was diluted with water (60 ml) and allowed to crystallize. The liquid was decanted and the residue was dissolved in methylene chloride and dried with magnesium sulfate. The organic residue was chromatographed on silica gel with hexanes/ethyl acetate (3:1) as eluent to give the desired product as a solid (m.p. 200-202° C.); NMR (CDCl3, 200 MHz) δ: 7.4-7.2 (3H), 4.2 (m, 2H), 3.9 (m, 2H).

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux
  3. customto crystallize
  4. customThe liquid was decanted
  5. dissolutionthe residue was dissolved in methylene chloride
  6. dry with materialdried with magnesium sulfate
  7. customThe organic residue was chromatographed on silica gel with hexanes/ethyl acetate (3:1) as eluent

출처 및 근거

ORD 기록
ord-12f4d8c9499f4b8895314806b25bd23b
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977028

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