Sodium Hydroxide → (+/-)-1-(2,6-Dimethylbiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

HRID 1600963노트

반응식

HRID 1600963 반응식
Cl[CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.[CH3:13][C:14]1[CH:19]=[C:18]([OH:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[OH-].[Na+]>C(O)C>[CH3:21][C:16]1[CH:17]=[C:18]([O:20][CH2:2][CH:3]([OH:12])[CH2:4][CH2:5][C:6]2[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:19]=[C:14]([CH3:13])[C:15]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 218306382,6-Dimethylbiphenyl-4-olHCID 22465338HCID 22465338, 화합물

생성물 1

HCID 21830751(+/-)-1-(2,6-Dimethylbiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol수율 55%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Prepared according to the method described in Example 24b) from (±)-α-(chloromethyl)-3-pyridinepropanol (0.70 g), 2,6-dimethylbiphenyl-4-ol (0.79 g), ethanol (15 ml) and aqueous sodium hydroxide (1.9 M, 2.5 ml). After work up the residue was purified by column chromatography over silica with ethyl acetate to give the title compound as a solid (0.72 g).

후처리

  1. customPrepared
  2. customAfter work up the residue was purified by column chromatography over silica with ethyl acetate

출처 및 근거

ORD 기록
ord-b8a79e300d224738aa69a44045bc9ae2
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977105

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