Ethanol → (2R)-1-(3'-Carboxybiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

HRID 1600966노트

반응식

HRID 1600966 반응식
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]([OH:26])[CH2:18][CH2:19][C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:11][CH:10]=2)[CH:6]=CC=1)#N.[OH-:27].[Na+].[CH2:29]([OH:31])[CH3:30]>O>[C:29]([C:30]1[CH:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]([OH:26])[CH2:18][CH2:19][C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:11][CH:10]=2)[CH:4]=[CH:3][CH:1]=1)([OH:27])=[O:31]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 54167436(2R)-1-(3'-cyanobiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

생성물 1

HCID 54073875(2R)-1-(3'-Carboxybiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A stirred solution of (2R)-1-(3'-cyanobiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol (0.60 g) and sodium hydroxide (0.696 g) in ethanol (8 ml) and water (2 ml) was heated at reflux for 10 hours. The mixture was concentrated and the residues dissolved in water and neutralised. The precipitate was filtered off and dried under vacuum to give the title compound as a white solid (0.616 g).

후처리

  1. temperatureat reflux for 10 hours
  2. concentrationThe mixture was concentrated
  3. dissolutionthe residues dissolved in water
  4. filtrationThe precipitate was filtered off
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-d935582cdc1f4a4c962f7951b2a6484b
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977105

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