Sodium Hydroxide → 2,5-Dimethyl-3-furoic acid

HRID 1601186

반응식

HRID 1601186 반응식
[CH3:1][C:2]1[O:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([O:9]CC)=[O:8].[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[O:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 1414573-Furancarboxylic acid, 2,5-dimethyl-, ethyl ester

생성물 1

HCID 694652,5-Dimethyl-3-furoic acid수율 85.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 3.2 g of ethyl 2,5-dimethylfuran-3-carboxylate, 35 ml of ethanol and 20 ml of 2 N sodium hydroxide was stirred at room temperature for 1.5 hours followed by heating under ref lux for an hour. After the reaction mixture was allowed to cool to room temperature, it was concentrated under reduced pressure. The residue was dissolved in water and acidified with diluted sulfuric acid. Precipitated crystals were collected by filtration, washed with water and dried to give 2.27 g of 2,5-dimethylfuran-3-carboxylic acid in a 85% yield.

후처리

  1. temperatureby heating under ref lux for an hour
  2. temperatureto cool to room temperature
  3. concentrationit was concentrated under reduced pressure
  4. dissolutionThe residue was dissolved in water
  5. customPrecipitated crystals
  6. filtrationwere collected by filtration
  7. washwashed with water
  8. customdried

출처 및 근거

ORD 기록
ord-0b79ee921d4c4a5da4958c25b9be5b52
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977168

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