Methyl iodide → Docosahexaenoyl choline iodide

HRID 1601334노트

반응식

HRID 1601334 반응식
[C:1]([O:24][CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])(=[O:23])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=[CH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].[I:30][CH3:31]>C(Cl)Cl>[I-:30].[C:1]([O:24][CH2:25][CH2:26][N+:27]([CH3:31])([CH3:29])[CH3:28])(=[O:23])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=[CH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 543902942-Dimethylaminoethyl docosahexaenoate

생성물 1

HCID 86754749Docosahexaenoyl choline iodide수율 96.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-dimethylaminoethyl docosahexaenoate (1.12 g, 2.80 mmol) in CH2Cl2 (10.0 mL) was added iodomethane (0.80 g, 5.60 mmol) dropwise at room temperature. The mixture was stirred at room temperature for 3 hr. The solvent and excess reagent was removed under reduced pressure and the residue was triturated with hexanes. The mixture was centrifuged and the supernatant was removed. The residue was dried under reduced pressure to provide the product, docosahexaenoyl choline iodide (1.46 g, 96%), as an off white solid.

후처리

  1. customThe solvent and excess reagent was removed under reduced pressure
  2. customthe residue was triturated with hexanes
  3. customthe supernatant was removed
  4. customThe residue was dried under reduced pressure

출처 및 근거

ORD 기록
ord-920d32ed0632460aae0a8d0141c6f04e
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977174

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