Water → HCID 18394418, 화합물

HRID 1602020노트

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HRID 1602020 반응식
[NH2:1][C@H:2]([CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[C:3]([OH:5])=[O:4].[C:12](OC(=O)C)(=[O:14])C.O>C(O)=O>[CH:12]([NH:1][C@H:2]([CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[C:3]([OH:5])=[O:4])=[O:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 7111750D-2-Thienylalanine

생성물 1

HCID 18394418HCID 18394418, 화합물

시약·촉매·용매 1

HCID 284Formic Acid용매

반응 조건

온도
0 °C

실험 절차

(2R)-2-Amino-3-(2-thienyl)propionic acid (5.00 g, 29.2 mmol) was dissolved in formic acid (50 ml). The solution was cooled to 0° C. Acetic acid anhydride (20 ml) was added dropwise. The reaction mixture was stirred for 16 h, while it was warming up to room temperature. It was cooled to 0° C. Water (20 ml) was added dropwise. The solution was warmed to room temperature. The solvent was removed in vacuo. The residue was suspended in ethyl acetate (20 ml). The precipitation was filtered off, collected, and dried in vacuo, to give 3.60 g of crude (2R)-2-(formylamino)-3-(2-thienyl)propionic acid, which was used for the following step.

후처리

  1. temperaturewas warming up to room temperature
  2. temperatureIt was cooled to 0° C
  3. temperatureThe solution was warmed to room temperature
  4. customThe solvent was removed in vacuo
  5. customThe precipitation
  6. filtrationwas filtered off
  7. customcollected
  8. customdried in vacuo

출처 및 근거

ORD 기록
ord-6ddae97f9a9c4b6da03f1514795152bf
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977178

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