Trimethyl orthoformate → 4,4-Dimethoxypiperidine

HRID 1602089노트

반응식

HRID 1602089 반응식
O.Cl.[NH:3]1[CH2:8][CH2:7]C(=O)[CH2:5][CH2:4]1.[CH:10](OC)([O:13][CH3:14])[O:11][CH3:12].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH3:12][O:11][C:10]1([O:13][CH3:14])[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]1

참가 물질

5

반응물 3

HCID 9005Trimethyl orthoformateHCID 521998p-Toluenesulfonic acid monohydrateHCID 2723901Piperonylamine

생성물 1

HCID 5574694,4-Dimethoxypiperidine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Into 9 ml of methanol were dissolved 0.69 g of 4-piperidone hydrochloride monohydrate, 0.74 ml of trimethyl orthoformate and 86 mg of p-toluenesulfonic acid monohydrate, and the reaction was conducted at room temperature for 24 hours. The reaction mixture was evaporated under reduced pressure to remove the solvent. The residue was dissolved into 2 ml of N,N-dimethylacetamide and admixed with 1.4 ml of triethylamine to give a solution of 4,4-dimethoxypiperidine.

후처리

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customto remove the solvent
  3. dissolutionThe residue was dissolved into 2 ml of N,N-dimethylacetamide

출처 및 근거

ORD 기록
ord-a9f177263f9d43879d3ff0225fa863ad
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981522

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