Sodium Dithionite → 1,3-Di-cyclopropyl-8-amino Xanthine

HRID 1602138

반응식

HRID 1602138 반응식
[CH:1]1([N:4]2[C:13](=[O:14])[C:12]3[NH:11][C:10]([N+:15]([O-])=O)=[N:9][C:8]=3[N:7]([CH:18]3[CH2:20][CH2:19]3)[C:5]2=[O:6])[CH2:3][CH2:2]1.S(S([O-])=O)([O-])=O.[Na+].[Na+]>CO.O>[CH:1]1([N:4]2[C:13](=[O:14])[C:12]3[NH:11][C:10]([NH2:15])=[N:9][C:8]=3[N:7]([CH:18]3[CH2:20][CH2:19]3)[C:5]2=[O:6])[CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 24489Sodium DithioniteHCID 98384921,3-Di-cyclopropyl-8-nitro xanthine

생성물 1

HCID 98136211,3-Di-cyclopropyl-8-amino Xanthine

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

1,3-Di-cyclopropyl-8-nitro xanthine (0.4 g, 0.0014 mol) was dissolved in methanol (20 ml) and treated with a sodium dithionite solution in water (0.5 g in 5 ml) at room temperature with stirring. After stirring for three hours the solvent was removed in vacuo, the residue taken up with dichloromethane and extracted with water (40 ml).

후처리

  1. stirringAfter stirring for three hours the solvent
  2. customwas removed in vacuo
  3. extractionextracted with water (40 ml)

출처 및 근거

ORD 기록
ord-109637f7e434403aa6fe7ef695e85977
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981535

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