N-bromobutanimide → HCID 19611696, 화합물

HRID 1602379노트

반응식

HRID 1602379 반응식
[Cl:1][C:2]1[C:10]2[O:9][CH:8]=[CH:7][C:6]=2[C:5]([CH3:11])=[CH:4][CH:3]=1.[Br:12]N1C(=O)CCC1=O>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C(Cl)(Cl)(Cl)Cl>[Br:12][CH2:11][C:5]1[C:6]2[CH:7]=[CH:8][O:9][C:10]=2[C:2]([Cl:1])=[CH:3][CH:4]=1

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 19611698HCID 19611698, 화합물

생성물 1

HCID 19611696HCID 19611696, 화합물수율 51.6%

시약·촉매·용매 2

HCID 7187Benzoyl Peroxide촉매HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of 7-chloro-4-methyl-benzofuran (CAS-number 79444-976; 51.9 g), N-bromosuccinimide (61.4 g), benzoyl peroxide (0.52 g) and carbon tetrachloride (1200 ml) was heated under reflux under the illumination of an 80 W flood lamp for 20 h. The mixture was cooled, and filtered and the filtrate evaporated to dryness. The residue was absorbed onto silica and purified by chromatography on silica using ethyl acetate and hexane (1:20) to give the title compound (39.50 g) as a yellow solid.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux under the illumination of an 80 W flood lamp for 20 h
  3. temperatureThe mixture was cooled
  4. filtrationfiltered
  5. customthe filtrate evaporated to dryness
  6. customThe residue was absorbed onto silica
  7. custompurified by chromatography on silica

출처 및 근거

ORD 기록
ord-9919571e6aea444d8b4e0ad277d78b28
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981572

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