Methyl morpholine oxide → HCID 19611677, 화합물

HRID 1602380노트

반응식

HRID 1602380 반응식
C[N+]1([O-])CC[O:5]CC1.Br[CH2:10][C:11]1[C:16]2[CH:17]=[CH:18][O:19][C:15]=2[C:14]([Cl:20])=[CH:13][CH:12]=1>C(#N)C>[Cl:20][C:14]1[CH:13]=[CH:12][C:11]([CH:10]=[O:5])=[C:16]2[C:15]=1[O:19][CH:18]=[CH:17]2

참가 물질

4

반응물 2

HCID 82029Methyl morpholine oxideHCID 19611696HCID 19611696, 화합물

생성물 1

HCID 19611677HCID 19611677, 화합물수율 73.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of the N-methylmorpholine-N-oxide (37.64 g) in aoetonitrile (370 ml) containing 3 Å molecular sieves (36.6 g) was stirred at room temperature overnight and cooled in ice. A solution of 4-bromomethyl-7-chloro-benzofuran (39.44 g) in acetonitrile (90 ml) was added and the mixture stirred in at 0° C. for 4 h. The mixture was filtered and the filtrate evaporated to dryness. Water and ethyl acetate were added to the residue and the organic phase separated, dried (Na2SO4) and evaporated to give the title compound (21.3 g) as a pale yellow solid.

후처리

  1. temperaturecooled in ice
  2. stirringthe mixture stirred in at 0° C. for 4 h
  3. filtrationThe mixture was filtered
  4. customthe filtrate evaporated to dryness
  5. additionWater and ethyl acetate were added to the residue
  6. customthe organic phase separated
  7. dry with materialdried (Na2SO4)
  8. customevaporated

출처 및 근거

ORD 기록
ord-e3b7f707ab4d4a74beb84622911d5f84
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981572

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