Hydrochloric Acid → HCID 19611685, 화합물

HRID 1602403노트

반응식

HRID 1602403 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[C:10]=1[CH2:11][CH2:12][CH2:13][NH:14]C(=O)C.[ClH:18]>>[ClH:18].[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[C:10]=1[CH2:11][CH2:12][CH2:13][NH2:14]

참가 물질

3

반응물 2

HCID 313Hydrochloric Acid2회HCID 19611697HCID 19611697, 화합물

생성물 1

HCID 19611685HCID 19611685, 화합물

실험 절차

N-[3-[2,3-Dihydro-5-fluorobenzofuran-4-yl]propyl]acetamide (0.55 g) was heated under reflux in 2M hydrochloric acid (10 ml) for 24 h. The mixture was cooled and washed with dichloromethane, basified with 2M sodium hydroxide and extracted with dichloromethane. Evaporation of the extracts gave an oil which was dissolved in 0.7M methanolic hydrogen chloride (8 ml). Evaporation gave the title compound as a beige solid (0.28 g).

후처리

  1. temperatureThe mixture was cooled
  2. washwashed with dichloromethane
  3. extractionextracted with dichloromethane
  4. customEvaporation of the extracts
  5. customgave an oil which
  6. customEvaporation

출처 및 근거

ORD 기록
ord-b48d778870094403815b84d4286d9c35
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981572

반응 노트

불러오는 중…