Sodium Hydroxide → 2,3-Dihydro-2,2-dimethyl-4-benzofurancarboxylic acid

HRID 1602449노트

반응식

HRID 1602449 반응식
C([CH:3]1[C:7]2=[C:8]([C:12]([OH:14])=[O:13])[CH:9]=[CH:10][CH:11]=[C:6]2[O:5][C:4]1([CH3:16])[CH3:15])C.[OH-].[Na+]>C(O)C>[CH3:15][C:4]1([CH3:16])[CH2:3][C:7]2=[C:8]([C:12]([OH:14])=[O:13])[CH:9]=[CH:10][CH:11]=[C:6]2[O:5]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 18787499HCID 18787499, 화합물

생성물 1

HCID 148382332,3-Dihydro-2,2-dimethyl-4-benzofurancarboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 2,2-dimethyl-2,3-dihydro-benzofuran-4-carboxylic acid (10 g, 45 mmol) was heated to reflux with sodium hydroxide (16.3 ml of 10N, 163 mmol) in ethanol (50 ml) for 2 hr. The mixture was concentrated in vacuo, diluted with water and made acidic with 12N HCl. The precipitate was filtered and air dried (8.6 g, 100%).

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. additiondiluted with water
  3. filtrationThe precipitate was filtered
  4. customair dried (8.6 g, 100%)

출처 및 근거

ORD 기록
ord-f510bad0af014321b2bf602f300d6a5d
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981571

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