Tetrahydrofuran → 3-(4,5,6,7-Tetrahydrobenzothiazol-2-ylmethoxy)benzoic acid

HRID 1602492노트

반응식

HRID 1602492 반응식
[S:1]1[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:4]=2[N:3]=[C:2]1[CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=1)[C:15]([O:17]C)=[O:16].O1CCCC1.[OH-].[Na+]>CO>[S:1]1[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:4]=2[N:3]=[C:2]1[CH2:10][O:11][C:12]1[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=1)[C:15]([OH:17])=[O:16]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 19611521Methyl 3-(4,5,6,7-tetrahydrobenzothiazol-2-ylmethoxy)benzoate

생성물 1

HCID 196115783-(4,5,6,7-Tetrahydrobenzothiazol-2-ylmethoxy)benzoic acid수율 75%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of methyl 3-(4,5,6,7-tetrahydrobenzothiazol-2-ylmethoxy)benzoate (361 mg, 1.2 mmol), tetrahydrofuran (2 ml), methanol (2 ml) and 1 N sodium hydroxide (2 ml) was stirred at room temperature for 12 hours and then concentrated under reduced pressure. The resulting residue was dissolved in water and the solution was adjusted to pH 3 by adding 10% citric acid aqueous solution. Thereafter, the solid substance formed was collected by filtration, washed with water, and then dried under reduced pressure to give 3-(4,5,6,7-tetrahydrobenzothiazol-2-ylmethoxy)benzoic acid (257 mg, 0.89 mmol, 75%).

후처리

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe resulting residue was dissolved in water
  3. additionby adding 10% citric acid aqueous solution
  4. customThereafter, the solid substance formed
  5. filtrationwas collected by filtration
  6. washwashed with water
  7. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-a7e677c24d794a738ca9e02d5e8b4ac4
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05981559

반응 노트

불러오는 중…