Acetic Anhydride → N-(3-bromo-5-nitrophenyl)acetamide

HRID 1603613

반응식

HRID 1603613 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([N+:9]([O-:11])=[O:10])[CH:8]=1)[NH2:5].[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1.O>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][C:12](=[O:14])[CH3:13])[CH:6]=[C:7]([N+:9]([O-:11])=[O:10])[CH:8]=1

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 44535ar-Bromo-ar-nitrobenzenamine

생성물 1

HCID 10658908N-(3-bromo-5-nitrophenyl)acetamide수율 91.5%

시약·촉매·용매 2

HCID 962Water용매HCID 1049Pyridine용매

실험 절차

28.40 g (0.131 mol) of 3-bromo-5-nitroaniline were dissolved in 250 ml of pyridine and treated with 30 ml (0.317 mol) of acetic anhydride. The mixture was stirred at room temperature for 18 hrs. and subsequently at 40° C. for 2 hrs. Then, the residue was digested in water and the precipitate was filtered off. The filter material was rinsed with a large amount of water and dried at 45° C. in a high vacuum. There were obtained 31.0 g (91.5%) of N-(3-bromo-5-nitrophenyl)-acetamide as orange-yellow crystals. MS (ISP): me/e=260, 258 (C8H8BrN2O3+).

후처리

  1. waitand subsequently at 40° C. for 2 hrs
  2. filtrationthe precipitate was filtered off
  3. washThe filter material was rinsed with a large amount of water
  4. customdried at 45° C. in a high vacuum

출처 및 근거

ORD 기록
ord-849c30a95b584c4cb3098744679e5144
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05990105

연결된 노트

불러오는 중…