Chlorotrimethylsilane → N-Ethyl-2-(trimethylsilyl)-1-naphthalenecarboxamide

HRID 1604231

반응식

HRID 1604231 반응식
[CH2:1]([NH:3][C:4]([C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=1)=[O:5])[CH3:2].[CH3:16][Si:17](Cl)([CH3:19])[CH3:18]>>[CH2:1]([NH:3][C:4]([C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][C:7]=1[Si:17]([CH3:19])([CH3:18])[CH3:16])=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 6397ChlorotrimethylsilaneHCID 4088726N-ethyl-1-naphthalenecarboxamide

생성물 1

HCID 19602329N-Ethyl-2-(trimethylsilyl)-1-naphthalenecarboxamide수율 58%

실험 절차

N-Ethyl-1-naphthalenecarboxamide was reacted with 2 eq TMSCl according to General Method C. The resulting reaction mixture was worked up in the usual manner, then purified by recrystallization from cold ethyl acetate/hexanes to afford 1.6 g of desired compound as a white solid, a 58% yield. m.p. 141-143° C.

후처리

  1. customThe resulting reaction mixture
  2. custompurified by recrystallization from cold ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-632443465f9a46ed8b8d291916272c7f
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994270

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