alpha-(3,4-Dichlorophenyl)-alpha-(2,6-dichloro-4-nitrophenyl)acetonitrile → 3,5-Dichloro-4-(3,4-dichloro-alpha-cyanobenzyl)aniline

HRID 1604310

반응식

HRID 1604310 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([C:12]2[C:17]([Cl:18])=[CH:16][C:15]([N+:19]([O-])=O)=[CH:14][C:13]=2[Cl:22])[C:10]#[N:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[H][H]>CO.[Ni]>[Cl:18][C:17]1[CH:16]=[C:15]([CH:14]=[C:13]([Cl:22])[C:12]=1[CH:9]([C:10]#[N:11])[C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)[NH2:19]

참가 물질

5

반응물 2

HCID 22008581alpha-(3,4-Dichlorophenyl)-alpha-(2,6-dichloro-4-nitrophenyl)acetonitrileHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 220085763,5-Dichloro-4-(3,4-dichloro-alpha-cyanobenzyl)aniline수율 95%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

In 100 ml of methanol were dissolved 7.6 g of α-(3,4-dichlorophenyl)-α-(2,6-dichloro-4-nitrophenyl)acetonitrile and 0.8 g (50%) of Raney's nickel. The solution was subjected to reduction with three times as much mol. of hydrogen gas. Insolubles were removed from the reaction mixture, then the remaining solution was concentrated to give the titled compound in a yield of 95%, m.p. 191-194° C.

후처리

  1. customInsolubles were removed from the reaction mixture
  2. concentrationthe remaining solution was concentrated

출처 및 근거

ORD 기록
ord-3d6cc99aef8646acb4aa74eba9d5226e
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994355

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