Acetic Acid → 4-(Pyridin-3-yl)-1,2-oxazol-5-amine

HRID 1604398노트

반응식

HRID 1604398 반응식
CN(C)[CH:3]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[C:4]#[N:5].Cl.[NH2:14]O.[C:16]([OH:19])(=O)C>>[NH2:14][C:16]1[O:19][N:5]=[CH:4][C:3]=1[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 443297Hydroxyamine hydrochlorideHCID 19603622HCID 19603622, 화합물

생성물 1

HCID 167406694-(Pyridin-3-yl)-1,2-oxazol-5-amine

반응 조건

온도
100 °C

실험 절차

To a solution of α-(dimethylamino)-α-(3-pyridyl)acetonitrile (5.19 g, 30 mmol) in acetic acid (40 ml) was added hydroxylamine hydrochloride (2.8 g, 40 mmol). The reaction mixture was stirred at 100° C. for 1 hour, cooled to room temperature and concentrated in vacuo. Water (50 ml) was added and the reaction mixture neutralized with solid potassium carbonate. The precipitated compound was filtered washed with water and dried giving the title compound in 4.2 g yield.

후처리

  1. temperaturecooled to room temperature
  2. concentrationconcentrated in vacuo
  3. additionWater (50 ml) was added
  4. filtrationThe precipitated compound was filtered
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-44726756555341708a135445766640bd
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994373

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