Toluene → (N-n-Butylcarbamoyl)methyltriphenylphosphonium Chloride

HRID 1604468노트

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HRID 1604468 반응식
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([CH:24]([Cl:28])[C:25]([NH2:27])=[O:26])CCC.[C:29]1([CH3:35])[CH:34]=[CH:33]C=CC=1>>[Cl-:28].[CH2:33]([NH:27][C:25]([CH2:24][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:26])[CH2:34][CH2:29][CH3:35]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 11776TriphenylphosphineHCID 573063372-Chlorohexanamide

생성물 1

HCID 19603925(N-n-Butylcarbamoyl)methyltriphenylphosphonium Chloride수율 89.1%

실험 절차

A solution of triphenyl phosphine (26.23 g, 0.1 mol) and n-butyl chloroacetamide (14.96 g, 0.1 mol) in toluene (250 mL) was refluxed with stirring for 22 h. After cooling to room temperature, the mixture was filtered and dried under high vacuum to afford 36.72 g (89.1% yield) of the title compound as white crystals. This material was used without further purification.

후처리

  1. filtrationthe mixture was filtered
  2. customdried under high vacuum

출처 및 근거

ORD 기록
ord-83fb0f28c8c84517b1b7d7cc335a14b7
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994396

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