Hydrochloric Acid → 8-(2,6-Dichloro-3-hydroxybenzyloxy)-2-methylquinoline

HRID 1604562노트

반응식

HRID 1604562 반응식
[Cl:1][C:2]1[C:20]([O:21]COC)=[CH:19][CH:18]=[C:17]([Cl:25])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[CH:11]2.Cl>CO>[Cl:1][C:2]1[C:20]([OH:21])=[CH:19][CH:18]=[C:17]([Cl:25])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[CH:11]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 196033098-[2,6-Dichloro-3-(methoxymethoxy)benzyloxy]-2-methylquinoline

생성물 1

HCID 196033608-(2,6-Dichloro-3-hydroxybenzyloxy)-2-methylquinoline수율 52.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 8-[2,6-dichloro-3-(methoxymethoxy)benzyloxy]-2-methylquinoline (1.57 g) in methanol was dropwise added conc. hydrochloric acid (2.7 ml) at 0° C., and the mixture was stirred for 5 minutes. The solvent was removed, and water was added thereto. The mixture was neutralized with saturated sodium bicarbonate solution, and the resulting participates were collected by filtration to give 8-(2,6-dichloro-3-hydroxybenzyloxy)-2-methylquinoline (734 mg) as a solid.

후처리

  1. customat 0° C.
  2. customThe solvent was removed
  3. additionwater was added
  4. filtrationthe resulting participates were collected by filtration

출처 및 근거

ORD 기록
ord-bee8461d7e4f4fbe85b6b04ff8ec518e
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994368

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