Hydrochloric Acid → 2-Methyl-4-phenylquinolin-8-ol

HRID 1604585노트

반응식

HRID 1604585 반응식
[OH:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=O)/[CH:10]=[CH:11]/[CH3:12].Cl.O.N>>[OH:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:3]=1[N:4]=[C:11]([CH3:12])[CH:10]=[C:9]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 58012-AminophenolHCID 231934Phenyl propenyl ketoneHCID 12896473Azane;hydrate

생성물 1

HCID 196034182-Methyl-4-phenylquinolin-8-ol수율 55.7%

실험 절차

A mixture of 2-hydroxyaniline (2 g), crotonoylbenzene (8.03 g) and concentrated hydrochloric acid (8 ml) was refluxed for 24 hours. The mixture was neutralized with concentrated ammonia water under ice-cooling, and extracted with chloroform. The organic layer was washed with brine, dried over magnesium sulfate and concentrated in vacuo. The residue was purified according to a conventional manner to give 8-hydroxy-2-methyl-4-phenylquinoline (2.4 g) as an oil.

후처리

  1. temperaturewas refluxed for 24 hours
  2. temperaturecooling
  3. extractionextracted with chloroform
  4. washThe organic layer was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated in vacuo
  7. customThe residue was purified

출처 및 근거

ORD 기록
ord-94f642f325e0476c8ea84bc8f709a403
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994368

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