Acetic Anhydride → 4-Acetamido-3-methoxybenzyl alcohol

HRID 1604588노트

반응식

HRID 1604588 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[O:10][CH3:11].[C:12](OC(=O)C)(=[O:14])[CH3:13]>CO>[C:12]([NH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[O:10][CH3:11])(=[O:14])[CH3:13]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 53420748(4-Amino-3-methoxyphenyl)methanol

생성물 1

HCID 538917484-Acetamido-3-methoxybenzyl alcohol수율 73.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4-amino-3-methoxybenzyl alcohol (900 mg) in methanol was added acetic anhydride (1.8 g) under ice cooling, and the mixture was stirred for 1 hour at the same temperature. After evaporation, the residue was dissolved in ethyl acetate, and the solution was washed with sodium bicarbonate solution, water and brine, dried over magnesium sulfate and concentrated in vacuo to give 4-acetamido-3-methoxybenzyl alcohol (840 mg) as solid.

후처리

  1. customAfter evaporation
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washthe solution was washed with sodium bicarbonate solution, water and brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-aa901595b69a4303a7e4603410e9a176
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994368

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