Tetrahydrofuran → 2-{2-{[2-(4-Tert-butylthiazol-2-yl)benzofuran-5-yloxy]methyl}phenoxy}pentanoic acid

HRID 1604694노트

반응식

HRID 1604694 반응식
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]4[CH:47]=[CH:46][CH:45]=[CH:44][C:22]=4[O:23][CH:24]([CH2:41][CH2:42][CH3:43])[C:25]([O:27]C(C4C=CC=CC=4)C4C=CC=CC=4)=[O:26])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].O1CCCC1.[OH-].[Na+]>CO>[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]4[CH:47]=[CH:46][CH:45]=[CH:44][C:22]=4[O:23][CH:24]([CH2:41][CH2:42][CH3:43])[C:25]([OH:27])=[O:26])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:2])([CH3:3])[CH3:4]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 19603769Diphenylmethyl 2-{2-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yloxy]methyl}phenoxy}-pentanoate

생성물 1

HCID 196038262-{2-{[2-(4-Tert-butylthiazol-2-yl)benzofuran-5-yloxy]methyl}phenoxy}pentanoic acid수율 52.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of diphenylmethyl 2-{2-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yloxy]methyl}phenoxy}-pentanoate (2.30 g) in a mixed solvent of tetrahydrofuran (30 ml) and methanol (15 ml) was added 1N sodium hydroxide solution (6.8 ml) at room temperature. The solution was stirred for two hours and concentrated under reduced pressure. The residue was diluted with water and acidified with 1N hydrochloric acid and was extracted with ethyl acetate. The organic layer was washed with brine and dried over magnesium sulfate to give 2-{2-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yloxy]methyl}phenoxy}pentanoic acid (901 mg).

후처리

  1. concentrationconcentrated under reduced pressure
  2. additionThe residue was diluted with water
  3. extractionwas extracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over magnesium sulfate

출처 및 근거

ORD 기록
ord-b611a46dc51748f7a0ef515d70f5b4d1
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994378

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