1,2-Epoxybutane → 3-Phenyl-2(S)-phthalimidopropan-1-al

HRID 1604747

반응식

HRID 1604747 반응식
[C:1]1([CH2:7][C@H:8]([N:12]2[C:16](=[O:17])[C:15]3=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]3[C:13]2=[O:22])[C:9](Cl)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1OC1CC>C1(C)C=CC=CC=1.[Pd]>[C:1]1([CH2:7][C@H:8]([N:12]2[C:16](=[O:17])[C:15]3=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]3[C:13]2=[O:22])[CH:9]=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 78341,2-EpoxybutaneHCID 105671973-phenyl-2(S)-phthalimidopropionyl chloride

생성물 1

HCID 110658013-Phenyl-2(S)-phthalimidopropan-1-al

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 1140Toluene용매2회

실험 절차

The solution containing the 3-phenyl-2(S)-phthal-imidopropionyl chloride was diluted with 500 ml of toluene and combined with 72.11 g of 1,2-butylene oxide. 23.5 g of palladium on carbon (5%) and 100 ml of toluene were added to the solution. The suspension was hydrogenated for 17 hours with stirring and then filtered and the residue washed with 200 ml of toluene, wherein 3-phenyl-2(S)-phthalimidopropan-1-al was obtained.

후처리

  1. filtrationfiltered
  2. washthe residue washed with 200 ml of toluene

출처 및 근거

ORD 기록
ord-48d3e33722a84601ad0fa0268b32d2cf
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05994555

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