Hydrochloric Acid → Pirbuterol Hydrochloride

HRID 1604956노트

반응식

HRID 1604956 반응식
[ClH:1].CC1(C)[O:8][C:7]2[CH:9]=[CH:10][C:11]([CH:13]([OH:20])[CH2:14][NH:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[N:12][C:6]=2[CH2:5][O:4]1>CO>[ClH:1].[ClH:1].[OH:4][CH2:5][C:6]1[C:7]([OH:8])=[CH:9][CH:10]=[C:11]([CH:13]([OH:20])[CH2:14][NH:15][C:16]([CH3:18])([CH3:17])[CH3:19])[N:12]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21428405α-[[(1,1-Dimethylethyl)amino]methyl]-2,2-dimethyl-4H-1,3-dioxino[5,4-b]pyridine-6-methanol

생성물 1

HCID 68658Pirbuterol Hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 10 ml. of methanol and 10 ml. of 10% hydrochloric acid is added 227 mg. of 2,2-dimethyl-6-(1-hydroxy-2-t-butylaminoethyl)-4H-pyrido[3,2-d]-1,3-dioxin, and the resulting reaction mixture allowed to stir at room temperature for 1.5 hrs. Removal of the solvents under vacuum at 70° C. provides 230 mg. of the desired product, which is identical by nuclear magnetic resonance spectroscopy to the product in U.S. Pat. No. 3,700,681.

후처리

  1. customRemoval of the solvents under vacuum at 70° C.
  2. customprovides 230 mg

출처 및 근거

ORD 기록
ord-8ce32a7bcc354aeaabf688ad27b29157
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03948919

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