Water → 7-Methylthio-3,7-dimethyloctan-1-al

HRID 1605142노트

반응식

HRID 1605142 반응식
[CH3:1][S:2][C:3]([CH3:13])([CH3:12])[CH2:4][CH2:5][CH2:6][CH:7]([CH3:11])[CH2:8][CH2:9][OH:10].C(N(CC)CC)C.O.CCCCCC>CS(C)=O>[CH3:1][S:2][C:3]([CH3:12])([CH3:13])[CH2:4][CH2:5][CH2:6][CH:7]([CH3:11])[CH2:8][CH:9]=[O:10]

참가 물질

6

반응물 4

HCID 962WaterHCID 8058HexaneHCID 8471TriethylamineHCID 215493537-Methylthio-3,7-dimethyloctan-1-ol

생성물 1

HCID 215493787-Methylthio-3,7-dimethyloctan-1-al

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매2회

실험 절차

To 2.04 g. (10 mmol.) of 7-methylthio-3,7-dimethyloctan-1-ol in 25 ml. of freshly distilled dimethylsulfoxide, under nitrogen at 20°, is added via syringe 11.2 ml. (80 mmol.) of triethylamine while stirring vigorously. Sulfur trioxide-2 pyridine complex (10.28 g., 64 mmol.) in dimethylsulfoxide (50 ml.) is added slowly to the mixture via dropping funnel under the same conditions. After addition is complete, the reaction mixture is stirred for 5 minutes and poured into cold water. Hexane is added and the organic layer separated, washed well with water and dried over calcium sulfate. Evaporation of the solvent at reduced pressure affords 7-methylthio-3,7-dimethyloctan-1-al.

후처리

  1. additionAfter addition
  2. customthe organic layer separated
  3. washwashed well with water
  4. dry with materialdried over calcium sulfate
  5. customEvaporation of the solvent at reduced pressure

출처 및 근거

ORD 기록
ord-79856178340d4dd8a22f1a10de38eaed
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03948996

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