Hydrochloric Acid → HCID 21546851, 화합물

HRID 1605545노트

반응식

HRID 1605545 반응식
[CH2:1]([NH:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([S:24](Cl)(=[O:26])=[O:25])[C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[OH-].[NH4+:30]>>[CH2:1]([NH:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([S:24](=[O:26])(=[O:25])[NH2:30])[C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 21546866HCID 21546866, 화합물

생성물 1

HCID 21546851HCID 21546851, 화합물

실험 절차

3-Benzylamino-5-chlorosulfonyl-4-phenylbenzoic acid (1.0 g) is in portions added to conc. ammonium hydroxide (10 ml) while stirring at 10°-12° C. After additional stirring at room temperature for about 18 hours, the resulting solution is dropwise added to an excess of icecold 4 N hydrochloric acid. The resulting precipitate is collected by filtration, washed with water and dried. After recrystallization from aqueous ethanol, 3-benzylamino-4-phenyl-5-sulfamylbenzoic acid is obtained with a melting point of 221°-222° C.

후처리

  1. stirringAfter additional stirring at room temperature for about 18 hours
  2. filtrationThe resulting precipitate is collected by filtration
  3. washwashed with water
  4. customdried
  5. customAfter recrystallization from aqueous ethanol

출처 및 근거

ORD 기록
ord-b10c56a25f4744ae9a63c6555c207773
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03950380

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