Hydrochloric Acid → HCID 22760937, 화합물

HRID 1605636노트

반응식

HRID 1605636 반응식
O=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[CH2:3]1.[O-]CC.[Na+].[CH3:21][C:22]([CH:24]=[CH2:25])=[O:23].Cl>C(O)C>[O:23]=[C:22]1[CH2:24][CH2:25][C:3]2[C:4]3[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=3[O:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C:2]=2[CH2:21]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6570Methyl vinyl ketoneHCID 2723922Sodium ethoxideHCID 11321766HCID 11321766, 화합물

생성물 1

HCID 22760937HCID 22760937, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To a solution of 42 g of the compound 10-keto-10,11-dihydrodibenzo(b,f)-oxepine in 200 ml of dry ethanol a solution of sodiumethoxide (7 g of sodium in 500 ml of ethanol) is added dropwise. After stirring the mixture for 30 minutes 16.2 ml of methylvinylketon in 50 ml of ethanol are added, whereupon the solution is refluxed for 1 hour. The solution is cooled then and poured into 2 N HCl. After extracting into ether, washing the ether layer with water (till neutral) and drying the etherial phase, the solvent is evaporated.

후처리

  1. additionare added, whereupon the solution
  2. temperatureis refluxed for 1 hour
  3. temperatureThe solution is cooled
  4. extractionAfter extracting into ether
  5. washwashing the ether layer with water (till neutral)
  6. customdrying the etherial phase
  7. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-e9c9777d53584b1797a134a5499425cc
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03950425

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