Ethanol → HCID 20566121, 화합물

HRID 1606141노트

반응식

HRID 1606141 반응식
[C:1]([C:11]1[N:15]([CH3:16])[C:14]([CH2:17][C:18]([O:20]C)=[O:19])=[CH:13][CH:12]=1)(=[O:10])[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[OH-].[Na+].C(O)C>O>[C:1]([C:11]1[N:15]([CH3:16])[C:14]([CH2:17][C:18]([OH:20])=[O:19])=[CH:13][CH:12]=1)(=[O:10])[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 18424261Methyl [5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-yl]acetate

생성물 1

HCID 20566121HCID 20566121, 화합물수율 87%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 3.00 g. (0.0105 mole) of methyl 5-(p-anisoyl)-1-methylpyrrole-2-acetate in 12 ml. (0.012 mole) of 1N sodium hydroxide solution and 5 ml. of 95% ethanol is refluxed for 30 minutes. The solution is diluted with water and the ethanol is evaporated in vacuo. The solution is filtered and the filtrate acidified with dilute hydrochloric acid. The precipitated solid is collected by filtration, dried and recrystallized from methanol-water to give about 2.4 g. (87% yield) of white 5-(p-anisoyl)-1-methylpyrrole-2-acetic acid, m.p. 170°-171°C.

후처리

  1. customthe ethanol is evaporated in vacuo
  2. filtrationThe solution is filtered
  3. filtrationThe precipitated solid is collected by filtration
  4. customdried
  5. customrecrystallized from methanol-water
  6. customto give about 2.4 g

출처 및 근거

ORD 기록
ord-1cbeb74ccb9c4728ad27a102abc52951
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03952012

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