Sodium Hydroxide → 1,4-Dimethyl-5-(p-fluorobenzoyl)-pyrrole-2-acetic acid

HRID 1606179노트

반응식

HRID 1606179 반응식
[CH3:1][N:2]1[C:6]([C:7](=[O:15])[C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[C:5]([CH3:16])[CH:4]=[C:3]1[CH2:17][C:18]([O:20]CC)=[O:19].[OH-].[Na+]>>[CH3:1][N:2]1[C:6]([C:7](=[O:15])[C:8]2[CH:9]=[CH:10][C:11]([F:14])=[CH:12][CH:13]=2)=[C:5]([CH3:16])[CH:4]=[C:3]1[CH2:17][C:18]([OH:20])=[O:19]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 18424154HCID 18424154, 화합물

생성물 1

HCID 185443041,4-Dimethyl-5-(p-fluorobenzoyl)-pyrrole-2-acetic acid수율 91%

실험 절차

A suspension of 3.03 g. (0.01 mole) of ethyl 1,4-dimethyl-5-(p-fluorobenzoyl)-pyrrole-2-acetate in 11 ml. of 1N sodium hyroxide solution is heated under reflux for 30 min. The solution is filtered while hot and acidified with dilute hydrochloric acid. The precipitate is collected, air dried and recrystallised from 2-propanol to give about 2.5 g. (91% yield) of 1,4-dimethyl-5-(p-fluorobenzoyl)-pyrrole-2-acetic acid as a white solid, m.p. 176°-178°C.

후처리

  1. additionA suspension of 3.03 g
  2. temperatureunder reflux for 30 min
  3. filtrationThe solution is filtered while hot and
  4. customThe precipitate is collected
  5. customair dried
  6. customrecrystallised from 2-propanol
  7. customto give about 2.5 g

출처 및 근거

ORD 기록
ord-28580c4a2b21472491596be4f64f9586
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03952012

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