HCID 86733267, 화합물 → N-Acetyl-DL-phenylglycine

HRID 1606259

반응식

HRID 1606259 반응식
[C:1]([NH:4][C:5](C1SC=CC=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1C)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]>[Ni].CC(C)=O>[C:1]([NH:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 86733267HCID 86733267, 화합물

생성물 1

HCID 85935N-Acetyl-DL-phenylglycine수율 73%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 180Acetone용매

실험 절차

Two (2.0) cc of Raney nickel (WII) was suspended in 15 ml of acetone, and refluxed for 7 minutes. Cooling the suspension to room temperature, 315 mg of α-acetylamino-α-tolylthiophenylacetic acid was added, followed by 5.5 hours' stirring at room temperature. The insoluble matter was separated by filtration, and washed with ethanol. The filtrate and washing were combined and concentrated under reduced pressure. The residue was crystallized from an ether-n-hexane system. Thus 141 mg of α-acetylaminophenylacetic acid was obtained. The yield was 73%.

후처리

  1. temperaturerefluxed for 7 minutes
  2. customThe insoluble matter was separated by filtration
  3. washwashed with ethanol
  4. washThe filtrate and washing
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was crystallized from an ether-n-hexane system

출처 및 근거

ORD 기록
ord-386f7d6536084da18b1ad9a9baae91ff
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03952044

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