Sodium Chloride → 4-Benzoyl-2,3-dihydro-1H-inden-1-one

HRID 1606718노트

반응식

HRID 1606718 반응식
[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][C:17]([OH:19])=O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[Cl-].[Na+]>O>[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:10]=1[CH2:15][CH2:16][C:17]2=[O:19])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 6451240Aluminum(III) ChlorideHCID 12286997Benzenepropanoic acid, 2-benzoyl-

생성물 1

HCID 131930944-Benzoyl-2,3-dihydro-1H-inden-1-one

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
160 °C

실험 절차

Five g. of o-benzoyl-β-phenylpropionic acid, 13 g. of anhydrous aluminum chloride and 1.3 g. of sodium chloride are admixed together and heated at 160°C for 1 hour. After cooling, water is added to the mixture, followed by extraction with chloroform. The extract is washed with a 5 % aqueous solution of sodium bicarbonate and water in that order and, then, dried. The solvent is distilled off under reduced pressure and the residue is dissolved in ethanol. The solution is decolorized with activated carbon and recrystallized from ethanol. The procedure yields 4-benzoylindan-1-one as crystals melting at 86°-88°C.

후처리

  1. temperatureAfter cooling
  2. extractionfollowed by extraction with chloroform
  3. washThe extract is washed with a 5 % aqueous solution of sodium bicarbonate and water in that order
  4. customdried
  5. distillationThe solvent is distilled off under reduced pressure
  6. dissolutionthe residue is dissolved in ethanol
  7. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-3e617f3e9cc742f38adf3420db637316
출처 데이터셋
uspto-grants-1976_04
특허 번호
US03953500

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