Water → 4-Methylthio-3-(trifluoromethyl)phenylboronic acid pinacol ester

HRID 16069

반응식

HRID 16069 반응식
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([B:9]([OH:11])[OH:10])=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13].O[C:17]([C:20](O)([CH3:22])[CH3:21])([CH3:19])[CH3:18].C(OCC)C.O>O1CCOCC1>[CH3:18][C:17]1([CH3:19])[C:20]([CH3:22])([CH3:21])[O:11][B:9]([C:6]2[CH:7]=[CH:8][C:3]([S:2][CH3:1])=[C:4]([C:12]([F:15])([F:13])[F:14])[CH:5]=2)[O:10]1

참가 물질

6

반응물 4

HCID 962WaterHCID 3283Diethyl EtherHCID 6425PinacolHCID 748911694-Methylthio-3-(trifluoromethyl)phenylboronic acid

생성물 1

HCID 672773014-Methylthio-3-(trifluoromethyl)phenylboronic acid pinacol ester

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

The product of step b) (0.25 g) was heated in dioxan (2 ml) with pinacol (2 equiv) for 3 h. The solution was treated with diethyl ether and water. The organic layer was separated, washed with brine, dried (Na2SO4) and concentrated in vacuo. Yield 85 mg.

후처리

  1. customThe organic layer was separated
  2. washwashed with brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-4377e4d71b804528910e589e09a43d88
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737135B2

연결된 노트

불러오는 중…