Acetic Acid → (E)-4-ethyl-2-methoxyimino-5-nitro-3-hexenamide

HRID 1606939노트

반응식

HRID 1606939 반응식
[CH2:1](/[C:3](/[CH:11]([N+:13]([O-:15])=[O:14])[CH3:12])=[CH:4]\[C:5](=[N:9][OH:10])[C:6]([NH2:8])=[O:7])[CH3:2].[N+](=[CH2:18])=[N-].C(O)(=O)C>CO>[CH2:1](/[C:3](/[CH:11]([N+:13]([O-:15])=[O:14])[CH3:12])=[CH:4]\[C:5](=[N:9][O:10][CH3:18])[C:6]([NH2:8])=[O:7])[CH3:2]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 9550DiazomethaneHCID 86742405(E)-4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide

생성물 1

HCID 86742404(E)-4-ethyl-2-methoxyimino-5-nitro-3-hexenamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To (E)-4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide (37 mg) in methanol (5 ml) was added excess etheral diazomethane at -20° C. The resulting mixture was allowed to stand at 0° C. for an hour and then acetic acid was added thereto until the yellow color of the solution was discharged. The resulting reaction mixture was evaporated under reduced pressure to give an oil which was purified by preparative thin layer chromatography, developing with chloroform containing 5% methanol to give (E)-4-ethyl-2-methoxyimino-5-nitro-3-hexenamide (21.5 mg).

후처리

  1. waitto stand at 0° C. for an hour
  2. customThe resulting reaction mixture
  3. customwas evaporated under reduced pressure
  4. customto give an oil which
  5. customwas purified by preparative thin layer chromatography

출처 및 근거

ORD 기록
ord-04395c6aa7d7415380eb349b5531032f
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04863926

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