Propylamine → HCID 178457528, 화합물

HRID 1607086노트

반응식

HRID 1607086 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][CH:9]=[N:10][C:11]#N)[N:3]=1.[CH2:13](N)[CH2:14]C>O>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][CH:9]=[N:10][CH2:11][CH2:13][CH3:14])[N:3]=1

참가 물질

4

반응물 2

HCID 7852PropylamineHCID 178512261HCID 178512261, 화합물

생성물 1

HCID 178457528HCID 178457528, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2.3 g (14 mmol) of N-(2-hydroxy-6-pyridyl)-N'-cyanoformamidine are added in portions at room temperature over a period of 20 minutes to a stirred solution of 8.3 ml (99 mmol) of n-propylamine in 8 ml of water The reaction mixture is stirred for 2 hours at room temperature It is then extracted three times with chloroform The combined organic phases are dried over MgSO4 and concentrated by evaporation. The resulting crude product is chromatographed on silica gel with methylene chloride and then crystallised from ether/n-hexane. N-(2-pyridon-6-yl)-N'-propylformamidine and N-(2-hydroxy-6-pyridyl)-N'-propylformamidine having a melting point of 178°-179° are obtained.

후처리

  1. extractionis then extracted three times with chloroform The combined organic phases
  2. dry with materialare dried over MgSO4
  3. concentrationconcentrated by evaporation
  4. customThe resulting crude product is chromatographed on silica gel with methylene chloride
  5. customcrystallised from ether/n-hexane

출처 및 근거

ORD 기록
ord-aad0c63e0b1e42f486e5574c2ef82aa0
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04863938

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